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It is often seen alongside: Ehlers-Danlos Syndrome (EDS) POTS (Postural Orthostatic Tachycardia Syndrome) Small Intestinal Bacterial Overgrowth (SIBO) Mold illness (CIRS) Lyme disease and co-infections Long COVID or post-viral syndromes Autoimmune disease (e.g., Hashimoto’s, lupus) Histamine intolerance Diagnosing MCAS MCAS is a clinical diagnosis, supported by lab testing